Monday 30 June 2014

pharmasist job in rgukt in telangana



Opportunity to work as Pharmacists (35 posts) in BSF | Government Job





















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Government of India
Ministry of Home Affairs
Directorate General Border Security Force
(Pers Directorate: Rectt Section)
// ADVERTISEMENT //
I. IMPORTANT INSTRUCTIONS TO CANDIDATES
1. BSF will hold an All India Examination for recruitment to the various posts of Para
Medical Staff in BSF for the year-2014.
2. Candidates are advised to go through the requirement of educational qualification, age,
physical standards, etc. and satisfy themselves that they are eligible for the posts,
before applying. BSF reserves the right to cancel the candidature of any candidate at
any stage of the selection process, if he is found not qualifying any of the prescribed
eligibility criteria. The detailed advertised is available on the website of the BSF
www.bsf.nic.in.
3. Candidates seeking reservation benefits for SC/ST/OBC/Ex-Servicemen must ensure
that they are entitled to such reservation as per eligibility prescribed in the notice.
They should also be in possession of the certificates in the format prescribed by
Government of India in support of their claim at the time of application.
4. Central Government Civilian Employees/Servants claiming age relaxation should be in
possession of a certificate in the prescribed format from their office, in respect of the
length of continuous service which should be for not less than three years in the
immediate period preceding the closing date for receipt of application(i.e. 14th
July 2014). They should continue to have the status of Central Government Civilian
Servants/Employees from the day of application till the time of appointment on the
basis of their performance in this examination to be eligible for such age relaxation.
5. Fee: Rupees Fifty only (Rs. 50/-) Fee is exempted for all women candidates and
candidates belonging to Scheduled Caste, Scheduled Tribe &Ex-Servicemen eligible for
reservation.
6. Closing Date: 14th July 2014 for all candidates. Applications received after closing
date and any enquiry in this regard will not be entertained by the Selection Board.
7. Mobiles and other Electronic Gadgets are banned within the premises of the
Examination Centers.
8. The selected candidate are liable to be posted anywhere in the Country as per the
transfer policy of the Force.
9. The recruitment will be done on All India Basis.
10. Selected candidate will be governed by BSF Act and Rules.
11. On appointment they shall be entitled for pension benefits as per the “New
Restructured Defined Contributory Pension Scheme” applicable for the new entrants to
the Central Government services w.e.f 01st Jan’ 2004.
12. Application duly filled up in the given format may be sent within 30 days from the date of
publication of Advertisement in the Employment News.
13. The application form (Annexure ‘A’) must be filled by the candidate in his/her own
handwriting / typewritten. Correction, if any, should be legible and attested by the candidate.
14. Applications, which are not on prescribed format or not accompanied by the required
enclosures or incomplete or defective shall be summarily rejected. No representation or
correspondence regarding such rejection shall be entertained under any circumstances.
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15. The envelope containing the application must be superscripted in bold letters as
“APPLICATION FOR THE RECRUITMENT OF PARA MEDICAL STAFF-2014”.
16. Candidate serving in Government/Semi Government/Public Sector undertakings should apply
through proper channel. No objection certificate from their employer will be required to be
submitted at the time of personal interview.
17. Candidates are not required to submit any original certificates in support to their claims. They
should ensure they fulfill all the eligibility conditions for admission to the tests and interview. If
on verification at a later stage it is found that they do not fulfill any of the eligibility
conditions, their candidature will be cancelled by the Selection Board.
18. Candidates are informed that written examination is only a preliminary test for screening and
short listing. No result of any of the tests will be supplied to the candidates and no
correspondence will be entertained by the Board in this regard.
19. All eligible candidates who apply in response to this advertisement before the closing date will
be assigned Registration/Roll Numbers. They will be communicated through Admit Cards for
appearing in the First Phase of the selection process i.e. Written Examination.
20. The recruitment board shall not be liable for any claim arising out of any injury etc. suffered
during the tests. The decision of the recruitment board shall be final in all matters connected
with this recruitment.
21. The decision of the selection board with regard to the matters connected with this recruitment
will be final in all respects.
22. The appointment will be subject to the conditions that the candidates are medically as well as
physically fit. The selected candidates will have to undergo Basic Training at any of the
Training Institutions of BSF. The services of those candidates who fail to complete the training
successfully are liable to be terminated.
23. An employee serving in the same rank and pay grade will not be entitled to apply for said post.
NOTE-I: Final scrutiny of eligibility criteria with regards to age, educational
qualification, caste, physical standard will be undertaken at the time of final
selection/medical examination. Therefore, candidature will be accepted only
provisionally till final selection. At the time of final selection when scrutiny is
undertaken and if any claim made in application is not found substantiated
then the candidature will be cancelled and the decision of BSF in this regard
shall be final.
NOTE-II: Success in the selection process confers no right to appointment unless the
candidates comes within the cut off merit list prepared as against the
advertised vacancies and the department is satisfied after such enquiry as may
be considered necessary that the candidate is suitable in all respects for
appointment to the service/post.
II. Applications are invited from male & female Indian citizens for appointment of following posts
(Group ‘B’ & ‘C’ Combatised) for Para Medical Staff in the Border Security Force, Ministry of
Home Affairs, Government of India. The post is temporary but likely to become permanent.
Name of
Post
Vacancies Age Pay Band
Plus
Grade
Pay
Education Qualification Gen/UR
SC
ST
OBC
Total
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SI (Staff Nurse)
(Group-B Post)
01 Nil Nil 07 08 21-30
years
Band Pay Rs. 9300-
34800/- Grade Pay
4200/-
Essential
(i) 10+2 or Equivalent
(ii) Degree/Diploma in General Nursing
Programme.
(iii) Registration as General Nurse and Midwife
with Central or State Nursing Council.
Desirable
Experience in the field of Tuberculosis,
Hospital Administration, Sister Tutor, Public
health, Pediatrics, Psychiatry.
ASI (Pharmacist-
Qualified)
(Group-C Post)
03 03 07 07 20 18-25
years
Band Pay Rs. 5200-20200/- Grade Pay- 2800/-
(i) 10+2 or equivalent
(ii) Degree or Diploma in Pharmacy from any
recognized Institution of the Central or
State Government for which the period of
Training in two years followed by an
internship of which the practical training
shall not be less than five hundred hours
spread over a period of not less than three
months.
Provided that not less than two hundred
and fifty hours are devoted to actual
dispensing of prescriptions.
(iii) Possessing the qualifications under
Section 31 & 32 of the Pharmacy Act,
1948 and registered under Section 33 of
the said Act.
ASI (OT
Technician)(
Group-C
Post)
01 Nil Nil 01 02 20-25
years
Essential
(i) 10+2 with Science or its equivalent plus
Diploma in Operation Technique or
Certificate in relevant subject from an
Institute recognized by the Central or the
State Government.
ASI (Physiotherapist)(
Gr
oup-C Post)
01 Nil Nil Nil 01 20-27
Years
(i) 10+2 with Science or equivalent from a
recognized board or Institution;
(ii) Degree or Diploma in Physiotherapy from an
Institution recognized by the Central or the
State Governments with 06 months
experience in a hospital of the Central or
State Government or in a hospital or in an
Institution recognized by the Central or
State Government is desirable.
HC (Electrician)
(Group-C Post)
01 Nil Nil Nil 01 18-25
Years
Band Pay Rs. 5200-
20200/- Grade Pay-
2400/-
Essential
(i) Matriculation or equivalent.
(ii) Diploma in Electrician trade from an
Institution recognized by the Central or the
State Government preferably from
Government Polytechnic or Industrial
Technical Institute with certificate or
competency.
(iii) Not less than three year practical experience
as an electrician.
CT
(Dresser)(Gr
oup-C Post)
01 - - - 01 18-25
Years
Band Pay Rs. 5200-
20200/- Grade Pay-
2000/-
(i) 10th or its equivalent from a recognized
board or Institution.
(ii) Possessing First Aid Certificate from St.
John’s Ambulance Organisation or Red Cross
Society of India or Para Medical Course in
related field.
(iii) Not less than one year experience in
bandage & dressing of wounds (preferably
in a hospital of the Central or the State
Government or in a hospital or an Institution
Page 4 of 20
recognized by the Central or State
Government).
CT (Peon) 01 Nil Nil Nil 01 18-23
Years
(a) Matriculation or equivalent from a
recognized Board with knowledge of
Cycling.
CT
(Masalchi)
02 Nil Nil 01 03 18-23
Years
(a) Pass in Matriculation or equivalent from a
recognized Board;
(b) (i) two years work experience in
respective trade; or
(ii) one year certificate course from a
recognized Industrial Training
Institute or Vocational Institute
with at least one year experience in
the trade; or
(iii)two years /Diploma from recognized
Industrial Training Institute in the trade
or similar trade.
Note: (i) Vacancies are subject to change (may increase or decrease)
(ii) Last date :14th July 2014 for all candidates.
(iii) Any amendment will only be published on BSF Website. Candidates in their own
interest are requested to regularly log on to www.bsf.nic.in for updates.
(iv) The crucial date for determining the age limit shall be the closing date for receipt of
applications i.e. 14th July 2014.
(v) 10% vacancies are reserved for Ex-Servicemen in each post
(a)Relaxation are as under:-
S/No Category Age Relaxation permissible beyond
the Upper age limit
(i) Scheduled Caste/ Scheduled Tribe 05 Years
(ii) Other Backward Classes 03 Years
(iii) For Group ‘B’ Post
Ex Servicemen (Unreserved)
05 Years
(iv) Ex Servicemen (OBC) 08 Years
(v) Ex Servicemen (SC/ST) 10 Years
(vi) For Group ‘C’ Post
Ex Servicemen (Unreserved/Gen)
03 Years after deduction of the military
service rendered from the actual age as on the
closing date.
(vii) Ex Servicemen (OBC) 06 Years (3 years + 3 years) after deduction of
the military service rendered from the actual
age as on the closing date.
(viii) Ex Servicemen (SC/ST) 08 Years (3 years + 5 years) after deduction of
the military service rendered from the actual
age as on the closing date.
(ix) Central Government Civilian Employees
(Unreserved/General) who have rendered not
less than 03 years regular and continuous
service as on Closing date.
05 Years
(x) Central Government Civilian Employees
(OBC) who have rendered not less than 03
08 (5+3)Years
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years regular and continuous service as on
Closing date.
(xi) Central Government Civilian Employees
(SC/ST) who have rendered not less than 03
years regular and continuous service as on
Closing date.
10 (5+5) Years
(xii) Candidates who had ordinarily been domiciled
in the State of Jammu & Kashmir
(Unreserved/General)
05 Years
(xiii) Candidates who had ordinarily been domiciled
in the State of Jammu & Kashmir (OBC)
08 (5+3) Years
(xiv) Candidates who had ordinarily been domiciled
in the State of Jammu & Kashmir (SC/ST)
10 (5+5) Years
(xv) Departmental Candidates (Unreserved) who
have rendered not less than 3 years of regular
and continuous service as on closing date.
05 Years
(xvi) Departmental Candidates (OBC) who have
rendered not less than 3 years of regular and
continuous service as on closing date.
08 (5+3) Years
(xvii) Departmental Candidates (SC/ST) who have
rendered not less than 3 years of regular and
continuous service as on closing date.
10 (5+5) Years
NOTE-I: The upper age limit is relaxable for Central Government Civilian Employees as
per extant Government order.
NOTE-II: The Crucial date for age-limit is reckoned with reference to the closing date for
receipt of applications (i.e14th July 2014).
NOTE-III: Candidates should note that the Date of Birth as recorded in the
Matriculation/Secondary Examination Certificate or an equivalent certificate
available on the closing date of submission of application(i.e. 14th July 2014)
will be accepted for determining the age eligibility and no subsequent request
for its change will be considered or granted.
NOTE-IV: Ex-Servicemen who have already secured employment in civil side under
Central Government in Group ‘C’ & ‘D’ posts on regular basis after availing of
the benefits of reservation given to ex-servicemen of their re-employment are
NOT eligible for fee concession or for claiming benefits of reservation under Ex-
Servicemen category. However, they are eligible for age relaxation.
NOTE-V: The period of “Call up Service” of an Ex-Servicemen in the Armed Forces shall
also be treated as service rendered in the Armed Forces for purpose of age
relaxation.
NOTE-VI: For any servicemen of the three Armed Forces of the Union to be treated as Ex-
Serviceman for the purpose of securing the benefits of reservation, he must have
already acquired, at the relevant time of submitting his application for the
Post/Service, the status of Ex-Serviceman and/or is in a position to establish his
acquired entitlement by documentary evidence from the competent authority that
he would complete specified term of engagement from the Armed Forces within
the stipulated period of one year from the Closing Date.
(b) PROCESS OF CERTIFICATION AND FORMAT OF CERTIFICATES:
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Candidates who wish to be considered against vacancies reserved/or seek agerelaxation
must submit requisite certificate from the competent authority, in the
prescribed format when such certificate are sought by the concerned selection board
at the time of Documentation&Interview. Otherwise, their claim for SC/ST/OBC/Ex-
Servicemen status will not be entertained and their candidature/applications will be
considered under General (UR) category. The formats of the certificates are
Annexed. Certificates obtained in any other format will not be accepted. Candidates
claiming OBC status may note that certificate on creamy layer status should have
been obtained within three year before the closing date (i.e. 14th July 2014) in the
prescribed format only. Certificates issued up to the last tier of examination i.e.
interview will also be accepted by the Selection Board.
NOTE-I: Candidates are warned that they will be permanently debarred from the
examination conducted by the BSF in case they fraudulently claim SC/ST/OBC/
Ex-S Status.
III. PHYSICAL STANDARDS
(a) For all advertised posts(except CT/Masalchi& CT/Peon)
Height Chest
Unexpended Expended
Male - 165 Cms, 76 Cms 81 Cms
Female - 150 Cms Not Applicable
(b) For the post of CT (Masalchi)
Height Chest
Unexpended Expended
Male - 167.5 Cms, 78Cms 83Cms
Female - 157Cms Not Applicable
Note1:-
The minimum height of candidates falling in the categories of Garhwalis, Kumaonis,
Gorkhas, Dogras, Marathas and candidates belonging to the states of Sikkim, Nagaland,
Arunachal Pradesh, Manipur, Tripura, Mizoram, Meghalaya, Assam, Himachal Pradesh, State
of Jammu and Kashmir will be 165 Cms for male and 155 Cms for Females. The minimum
height for all candidates belonging to Scheduled Tribes will be 162.5 Cms for males and 150
Cms for female.
Note2:-
The minimum chest for male candidates falling in the categories of Garhwalis,
Kumaonis, Gorkhas, Dogras, Marathas and candidates belonging to the states of Sikkim,
Nagaland, Arunachal Pradesh, Manipur, Tripura, Mizoram, Meghalaya, Assam, Himachal
Pradesh, State of Jammu and Kashmir will be 78 Cms. (minimum 5 Cms expansion). The
minimum chest for all male candidates belonging to Scheduled Tribes will be 76 Cms
(minimum 5 Cms expansion).
(c) For the post of CT (Peon)
Height Chest
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Unexpended Expended
Male - 167.5 Cms 78Cms 83Cms
Female - 157Cms Not Applicable
IV. (a) MEDICAL STANDARD FOR ALL ADVERTISED POSTS (EXCEPT
CT/MASALCHI& CT/PEON)
(i) Should be medically fit in all respects. (Visual standard should be 6/6 to right eye and
6/12 left eye or 6/9 both eye without optical device).
(ii) The candidates should not have knock knees, flat foot, varicose vein or squint in eyes
and they should possess high colour vision. The candidates shall be tested for colour
vision by Ishahara’s test as well Edrich-Green Lantern Test. They must be in good
mental and bodily health and free from any physical defect likely to interfere with the
efficient performance of the duties.
(iii) Weight – Corresponding to height and age.
(b) MEDICAL STANDARD FOR CT(MASALCHI) & CT (PEON)
(i) Vision – Minimum distant vision should be 6/6 and 6/9 of both eyes without correction
(i.e. without wearing glasses).
(ii) Must pass high grade colour vision test. Must not have knock-knees, flat feet or squint
in eyes. Must not have any defect or deformity which likely to interfere with the
efficient performance of the duties.
(iii) Weight – Corresponding to height and age.
V. DISQUALIFICATION
(i) No person
(a) Who has entered into or contracted a marriage with a person having spouse
living. Or
(b) Who having a spouse living, has entered into or contracted a marriage with
another person.
Shall be eligible for appointment to the Force, provided that the Central Government
may, if satisfied that such marriage is permissible under the personal law applicable to
such person and the other party to the marriage and there are other grounds for so to
do, exempt any person from the operation of this rule.
(ii) Conviction by any Court of Law.
(iii) Dismissal from Government Service.
(iv) Termination from BSF during probation.
VI. SELECTION PROCEDURE
The selection procedure will be as under:-
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FIRST PHASE OF THE EXAMINATION
(a) Written Examination
There will be one composite paper each for the above mentioned posts according to
syllabus mentioned against each. Examination will be conducted on OMR Answer
Sheets each question carrying one mark (OBJECTIVE TYPE MULTIPLE
CHOICE). Duration of question paper for all posts (except CT/Peon & CT/Masalchi)
will be two hours and duration of question paper for the post of CT/Peon &
CT/Masalchi will be one hour.
Note:- The minimum qualifying marks of Written Exam for General & OBC
Category is 45% and for SC/ST Category is 40%.
Syllabus:-
(i) Syllabus for the post of SI (Staff Nurse)
 Part-I General Knowledge and numerical aptitude - 25 Marks
 Part-II Human Anatomy & Physiology - 25 Marks
 Part-III Professional - 50 Marks
 Medical & Surgical Nursing
 Health & Illness
 Nursing Care of persons
 Pregnancy &Labour
 Midwifery
Total -100 Marks
(ii) Syllabus for the post of ASI (Pharmacists- Qualified)
 Part-I General Knowledge and numerical aptitude - 25 Marks
 Part-II - 25 Marks
 Pharmaceutics
 Pharmaceutical Chemistry
 Pharmacognosis
 Part-III - 25 Marks
 Human Anatomy
 Physiology
 Pathology
 Part-IV - 25 Marks
 Basic Nursing
 Health Education
Total -100 Marks
(iii)Syllabus for the post of ASI (OT Technician)
 Part-I General Knowledge and numerical aptitude - 25 Marks
 Part-II Human Anatomy & Physiology - 25 Marks
 Part-III - 50 Marks
 General Surgical principles
 Fundamental concepts and procedures related to operation theatre
and techniques
 Anesthetic drugs & equipment and surgical operation theatre tray
set up
 Sterilization & Disinfectants
Total -100 Marks
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(iv)Syllabus for the post of ASI (Physiotherapist)
 Part-I General Knowledge and numerical aptitude - 25 Marks
 Part-II Human Anatomy & Physiology - 25 Marks
 Part-III - 50 Marks
 Fundamental of Biochemics& Exercise Therapy
 Principles of Bio-electrical modalities & Electro Therapy
 Physical & Electro Therapy
 Physiotherapy – Orthopedics/Sports Neurology, Cardio
Respiratory/ Rehabilitation & Geriatrics
Total -100 Marks
(v)Syllabus for the post of HC (Electrician)
 Part-I Numerical aptitude - 20 Marks
 Part-II General Knowledge & General Reasoning - 20 Marks
 Part-III Professional - 60 Marks
 From the syllabus of ITI in Electrician trade
Total -100 Marks
(vi)Syllabus for the post of CT (Dresser)
 Part-I General Knowledge and numerical aptitude - 25 Marks
 Part-II Fundamental principles of First Aid/Dressing - 25 Marks
 Part-III Professional - 50 Marks
 Type of fracture, Injuries & application of Bandage
 Dressing, Sterilization & Disinfectants
 Principles and use of first aid equipment/kits and reporting
incidents
 Cardio Pulmonary Resuscitation
Total -100 Marks
(vii) Syllabus for the post of CT (Peon)& CT (Masalchi)
 Part-I General Knowledge, General Awareness - 15 Marks
Including Environmental sanitation
 Part-II General Intelligence & reasoning - 15Marks
 Part-III Elementary Mathematics - 10 Marks
 Part-IV English/Hindi Language Test - 10 Marks
Total - 50 Marks
SECOND PHASE OF THE EXAMINATION
Candidates declared qualified in the first phase of Examination (written
examination) will be permitted to appear before the selection board for second phase of
the Examination on due date, which will be communicated to them through BSF Website.
They will be put through subsequent stages. Candidates have to qualify all the stages of
Second phase examination. If any candidate fails to qualify in any of the events of the
examination, he will not be allowed to participate in further stages of the examination
process.
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(a) Documentation
 Age :The date of birth as recorded in the matriculation certificate will only be
considered for determining the age of the candidate as on 14th July 2014.
 Caste Certificate :The caste certificates produced by candidates should be those
issued by competent authority in support of their claim of belonging to SC/ST
and OBC. The board is competent to take final decision in accepting / rejecting
a candidate if he does not produce satisfactory / convincing documents.
 Educational Qualification :The original certificates issued by the recognized
Universities/Boards will be checked by the board.
(b) Physical Measurement
Candidates whose documents are found to be in order will be allowed to appear for the
physical measurement. Candidates shall be screened and only those who satisfy the minimum
physical standards as per para-III above shall be allowed to appear for the PET.
(c) Physical Efficiency Test (For the all posts):-
Event Male Female Remarks
1 Km Run 06 Minutes 08 Minutes
Long Jump 09 Feet 07 Feet Max 03 Attempts
High Jump 3 feet 6 Inches 03 feet Max 03 Attempts
(d) Interview
The candidates will appear for Interview. The Interview carries 50 marks. The
qualifying marks for General / OBC candidates shall be 45% and for SC/ST candidates it shall
be 40%. Break-up of marks are as under:-
 Professional knowledge = 35 marks
 General knowledge = 10 marks
 Personality = 05 marks
Total = 50 marks
(e) Trade Test
Candidates for the post of CT (Masalchi) and CT (Peon) must qualify the respective
trade test.
(f) Medical examination
Candidates who secure minimum qualifying marks in the interview will be subjected to
detailed medical examination so as to assess their fitness for appointment in BSF as per laid
down standards. The medical examination will be held immediately after completion of
interview at the respective interview centres.
NOTE –I: Ex-servicemen applying for the posts are not required to undergo PET.
However, all the Ex-Servicemen are required to pass the written test and fulfill
the physical standards prescribed for Direct Entry candidates to the above
posts, as the case may be. They should also pass the medical standards
prescribed for Direct Entry Candidates.
Page 11 of 20
NOTE-II : Candidates declared disqualified in Physical Standards, i.e. height and chest,
may prefer an appeal immediately at the venue of the PST itself, if they so
desire, to the Board of Officer/Presiding Officer present on the PST/PET
ground. The decision of the Board of Officer/Presiding Officer will be final and
no further appeal or representation in this regard will be entertained.
NOTE-III: Candidates are not permitted to use Mobile Phone, Calculator or any other
electronic/electrical device for answering any paper(Test Booklets). Candidates
must not therefore, bring Mobile Phone, Calculator or any other electronic
electrical device inside the Examination premises. Possession of these items,
whether in use or not, will be considered as “use of unfair means” in the
Examination and appropriate action will be taken by the department against
such candidates, as per extant policy of the department.
NOTE-IV: Medical Examination – Those who qualify in the Written Examination,
Documentation, Physical Measurement, Physical Efficiency Test &
Interviewwill go through Medical Examination to assess their fitness. If found
Unfit in the Medical Examination, they may prefer for an appeal for Review
Medical Examination within the prescribed time limit of 15 days. The provision
for appeal for Review Medical Examination is only against an error of
judgment of the Medical Examination Board. On acceptance of the appeal
Review Medical Examination will be conducted and the decision of Review
Medical Board will be final and no appeal/representation against the decision of
the Review Medical Board will be entertained.
VII. MODE OF PAYMENT
Male candidates applying for Recruitment to the above posts should enclose alongwith
their applications a Postal order or bank draft for Rs.50/- as examination fee to be drawn in
favour of theDDO of respective Examination Centres payable at respective branch, as
mentioned at para No. VIII below.SC/ST and Female Candidates are exempted from
paying examination fee.
NOTE-I: Fee once paid will not be refunded under any circumstances.
NOTE-II: Fee paid by modes other than IPO/BD, as stated above, will not be accepted
and the applications of such candidates will be rejected forthright and the
payment made shall stand forfeited.
VIII. SUBMISSION OF APPLICATION
HOW TO APPLY:
(a) Application duly filled upin the given format may be sent to any one of the following
addresses nearest to the candidate within 30 days from the date of publication of
advertisement in the employment news:-
Name of Centre Centre
Code
Name of Recruiting
Agencies/Application
receiving centres with
Address
IPO/BD to be prepared in
favour of /payable at bank
Srinagar (J&K) 011 Frontier HQ BSF Srinagar,
Sanatnagar, Indl Estates,
Srinagar (J&K)
“IG BSF Srinagar”
SBIBarzulla, Srinagar, Code
No. 1527
Page 12 of 20
Jammu 012 Frontier HQ BSF Jammu,
Paloura Camp, Jammu
(J&K)-181124
“IG BSF Jammu” SBI Jammu
Code No. 0657 or PNB
Jammu
Jalandhar 013 Frontier HQ BSF Punjab,
Jalandhar Cantt (Punjab)
Pin-144006
“IG BSF Punjab Ftr” SBI
BSF Campus Jalandhar, Code
No. 6596
Gandhi Nagar 014 Frontier HQ BSF Gujarat,
PO- CRPF Group Centre
Chiloda Road, Gandhinagar,
Gujarat-382042
“IG BSF Gujarat” SBI GC
CRPF Gandhinagar, Code
No. 6825
Jodhpur 015 Frontier HQ BSF Rajasthan,
PO- BSF Campus Mandore
Road, Jodhpur (Rajasthan)-
342026
“IG BSF Rajasthan”,
SBIRaiKaBagh, Code No.
7451
Kadamtala 016 Frontier HQ BSF North
Bengal, PO-Kadamtala,
Siliguri, Distt-Darjeeling
(WB), Pin-734011
“IG BSF North Bengal”
SBINBU Campus Siliguri,
Code No. 2096
Kolkata 017 Frontier HQ BSF South
Bengal, 2-B, Lord Sinha
Road, Kolkata (WB)-700071
“IG BSF South Bengal”
SBIChowringhee Kolkata,
Code No. 1054
Silchar, Imphal 018 Frontier HQ BSF M&C, POArunachal,
Distt-Cachar
(Assam)-788025
“IG BSF M&C Frontier”,
SBIArunachal, Code No.
5541
Shillong 019 Frontier HQ BSF AM, POUmpling,
Distt-East Khasi
Hills, Shillong (Meghalaya)-
793006
“IG BSF Shillong”,
SBILaitumkhrah, Code No.
2081
Agartala, Tripura 020 Frontier HQ BSF Tripura,
PO-Salbagan, Agartala
(Tripura)-799012
“IG BSF Tripura”,
SBISalbagan, Code No. 4570
Hazaribagh 021 TC&S, BSF, Meru Camp,
Hazaribagh, Jharkhand-
825317
“IGTC&S BSF Hazaribagh”,
SBIMeru Camp, Code No.
2922
Indore 022 CSWT BSF Indore, Bijasan
Road, Indore (MP)
“DIG CSWT BSF Indore, SB
BSF Campus Indore, Code
No. 4518
Delhi 023 Commandant 25 Bn BSF,
Chhawla Camp, POChhawlaNajafgarh,
New
Delhi-71 (Under IG HQ
FHQ)
“Commandant 25 Bn BSF”
SBINajafgarh, A.D.B., Code
No. 1419
Ftr HQ Bangalore 024 Frontier HQ BSF Bangalore,
PO : Yelahanka, Bangalore,
Karnataka-560064
“IG BSF Bangalore”
SBIAFSYelahanka, Code No.
2187
Tekanpur,
Gwalior
025 BSF Academy Tekanpur,
PO-Tekanpur, Gwalior
(MP)-475005
“IG& Director BSF Academy
Tekanpur” SBITekanpur,
Code No. 8284

Page 14 of 20
“APPLICATION FOR THE VARIOUS POSTS OF PARA MEDICAL STAFF-2014”
(This form should be filled in by the candidate in his own handwriting neatly and legibly in block
letters. It should be completed in all respects and should be accompanied by certified copies
of testimonials. A copy of recent passport size photograph should also be pasted on the
application at the space provided for the purpose. Incomplete application will not be entertained
and will be summarily rejected).
Registration No.______________________ ROLL NO______________________
(To be filled by office) (To be filled by office)
.
POST APPLIED FOR __________________________________
1. Full Name in Capital letters : ________________________________________
(Surname, if any first)
2. Father/Husband name : ________________________________________
3 Date of Birth (According to Christian : In words __________________________
era as recorded in the Matriculation or In figures __________________________
equivalent certificate)
4. Permanent Address with Mobile No. : ________________________________________
________________________________________
________________________________________
5. Correspondence address with Mobile No : ________________________________________
and E-Mail Address (if available) ________________________________________
________________________________________
6. Nationality : ________________________________________
7. Religion(Hindu/Muslim/Sikh/Christian etc) : ________________________________________
8. Category (General/OBC/SC/ST) : ________________________________________
9. Sex (Male/Female) : ________________________________________
10. Marital Status : ________________________________________
11. Visible Identification Marks : ________________________________________
12. Educational qualification : ________________________________________
13. Professional qualification : ________________________________________
14. Details of examinations passed including professional courses starting from
Matriculation/School leaving certificate onwards:-
Paste here
self attested
recent
passport size
photograph
Page 15 of 20
Name of School Name of recognized Board/
University of Examinations
Examination
passed.
Division/
Class
obtained
%age of
marks
obtained
15. Particulars of present employment : ________________________________________
if any, with post and personal number/ ________________________________________
department etc. ________________________________________
16. List of enclosures : ________________________________________
________________________________________
________________________________________
________________________________________
DECLARATION
I hereby declare that all statements made in this application are true, complete and correct
to the best of my knowledge and belief. I understand that in the event of any information being
found suppressed/false or incorrect or ineligibility being detected before or after the
examination, my candidature/appointment is liable to be cancelled.
Station:
Date : Signature of the applicant
NOTE:-
i) The candidate shall produce the original certificates at the time of Documentation and
Interview. Non-production of certificates shall be a disqualification.
ii) Candidate in service must submit their application through proper channel with the
certificate duly signed by their employer stating their willingness to release them from
service in the BSF in case they are selection.
Page 16 of 20
Directorate General Border Security Force
(Personnel Directorate : Recruitment Section)
Admit card for the various posts of Para Medical Staff in BSF - 2014
Registration No.__________________
Roll No._________________________
1. Name of candidate : ________________________________________
2. Father/husband’s name : ________________________________________
3. Date of birth : ________________________________________
4. Postal Address with Mobile No. : ________________________________________
________________________________________
________________________________________
5. Category(Gen/SC/ST/OBC) : ________________________________________
6. Personal mark of identification : ________________________________________
________________________________________
________________________________________
7. Applied for the post of : ________________________________________
Signature of the candidate
(To be filled by the office)
8. Centre of examination : ________________________________________
9. Date of examination : ________________________________________
Paste here
self attested
recent
passport size
photograph
Page 17 of 20
Annexure –‘B’
FROM OF CERTIFICATE TO BE PRODUCED BY A CANDIDATEIN SUPPORT OFCLAIM TO
BELONG TO SCHEDULED CASTE/ SCHEDULED TRIBE OR ANGLO INDIAN COMMUNITY
This is to certify that ________________________________________________ Son
of____________________________________ Resident of village _______________________ District/Division
___________________ State __________________ belong to the _________________ community which is
recognized Scheduled Caste/Tribe under Constitution (Scheduled Castes) under 1950 the
constitution (Schedule Tribes) order 1950/ the Constitution of Scheduled castes ( Part C states )
order 1951.
Shri_________________________________ and / or his family ordinarily reside (s) in
the______________________________ District/Division of the ________________ State.
Dated ___________ District Magistrate
Deputy Commissioner
Note :-
(i) The term ordinarily reside used here will have the same meaning as in section 20
ofthe representation of the people Act 1950.
(i) Where the certificate are issued by Gazetted Officer of the Union Govt or state
Governments. They should be in the same form but countersigned by the District
Magistrate or Deputy Commissioner ( Certificate issued by the Gazetted Officers
and attested by District Magistrate/Deputy Commissioner are not sufficient)
Page 18 of 20
ANNEXURE – ‘C’
FORM OF CERTIFICATE TO BE PRODUCED BY OTHER BACKWARDCLASSES APPLYING FOR
APPOINTMENT TO THE POST UNDERGOVERNMENT OF INDIA
(G.I. Dept. of Per.&Trg, O.M. No. 35033/28/94-Estt(SCIO, dated 23-11-1995)
This is certify that ___________________________son of _________________________ of
Village_________________________District/Division__________________________________ in
the_____________________ State_____________________ belongs to the ________________ community which is
recognized as a Backward Class, under:-
 (i) Government of India, Ministry of Welfare, Resolution No. 12011/68/93-
BCC, dated the 10th September, 1993 published in the Gazette of India,
Extraordinary, Part I, Section I, No . 186, dated the 13th September, 1993.
 (ii) Government of India, Ministry of Welfare, Resolution No. 12011/9/94-BCC,
dated 19-10-1994, published in the Gazette of India, Extraordinary, Part I,
Section I, No. 163, dated 20-10-1994.
 (iii) Registration No. 12011/1/95 BCC dated 24th May, 1995, published in the
Gazette of India, Extraordinary, Part 1, Section 1, No. 88 dated 25-5-1995.
Shri ______________________ and/or his family ordinarily reside(s) in the
______________District/Division of the _______________State. This is also to certify that he/she
does not belong to the persons/sections (Creamy layer) mentioned in Column 3 of the
Schedule to the Government of India, Department of Personnel and Training, O.M. No.
36012/22/93-Estt (SCT), dated 8-9-1993.
Dated :
District Magistrate/
Deputy Commissioner,etc.
With Stamp
* Strike out whichever is not applicable.
Page 19 of 20
ANNEXURE – ‘C-1’
DECLARATION BY OBC CANDIDATE REGARDING NON-CREAMY LAYER STATUS
I, ___________________________Son / Daughter of Shri ________________________
Resident of village/town/city____________________________ district_______________________
State_____________________ hereby declare that I belong to the__________________ community which is
recognized as a backward class by the Government of India for the purpose of reservation in
services as pr orders contained in DOP&T OM No. 36012/22/93-Estt.(SCT) dated 08.9.93. It is
also declared that I do not belong to persons/sections (Creamy Layer) mentioned in column 3
of the Schedule to the above referred Office Memorandum dated 08.9.93.
Signature of the applicant (OBC Candidate)
Page 20 of 20
ANNEXURE – ‘D’
FORM OF CERTIFICATE TO BE SUBMITTED BY THE CANDIDATES THOSEWHO INTEND TO
AVAIL RELAXATION IN HEIGHT OR CHEST MEASUREMENT
Certified that Shri _______________________S/O Shri ____________________________ is permanent
resident of village________________________ Tehsil/Taluka________________ District______________ of
________________State.
2. It is further certified that :-
*Residents of entire area mentioned above are considered as (Garhwal,Kumaouni, Dogras,
Marathas, Sikkimies) for relaxation in height and chest measurement for recruitment in the Para
Military forces of the Union of India.
*He belongs to Himachal Pradesh/Leh&Laddakh/Kashmir Valley/North Eastern States and is
considered for relaxation in height and chest measurement for recruitment in the Para Military
forces of Union of India.
*He belongs to __________________ Tribals/Adivasis Community and is considered for relaxation in
height and chest measurement for recruitment in the Para military forces of the Union of India.
Dated :
Place :
Signature
District Magistrate/
Sub Divisional Magistrate/Tehsildar
* Delete whichever is not applicable.

Tuesday 29 October 2013

Tuesday 12 March 2013

CODES FOR COLOGY AND COGNOSY DRUGS




1)Kreb cycle
Can an intelligent officer kiran succesfully solve foreign mafia operation
citrate-aconitase-isocitrate-oxalosuccinate- ketoglutarate(alpha k.g.)-succinate-fumarate-malate-oxaloacetate
20ESSENTIAL AMINO ACIDS
My True love is through valentine love phrases Methionine,threonine,leucine,isoleucine,tryptophan,valine,lysine,phenylalanine
3)BUSULFAN FEATURES ABCDEF:
 Alkylating agent, Bone marrow suppression ,CML indication ,Dark skin (hyperpigmentation) Endrocrine insufficiency (adrenal), Fibrosis (pulmonary)
4)DRUGS CAUSING TORSADES DE POINTES (APACHE)
 Amiodarone Procainamide Arsenium Cisapride Haloperidol Eritromycin

 5)MORPHINE:SIDE-effects (MORPHINEJ
 Myosis, Out of it (sedation), Respiratory depression, Pneumonia (aspiration) ,Hypotension Infrequency (constipation, urinary retention) ,Nausea ,Emesis
6)ASPIRIN SIDE EFFECTS (ASPIRIN)
 Asthma Salicyalism Peptic ulcer disease/ Phosphorylation-oxidation uncoupling/ PPH/ Platelet disaggregation/ Premature closure of PDA Intestinal blood loss, Reye's syndrome Idiosyncracy Noise (tinnitus)
6)SSRIS: SIDE EFFECTS SSRI:
Serotonin syndrome , Stimulate CNS , Reproductive disfunctions in male,  Insomnia

7)INHALATION ANESTHETICS (SHINE):
Sevoflurane , Halothane,  Isoflurane,  Nitrous oxide, Enflurane.
8) TERATOGENIC DRUGS 9"Win TERATOgenic  
 Warfarin,  Thalidomide, Epileptic drugs: (phenytoin, valproate, carbamazepine, Retinoid ,            ACE inhibitor Third element: lithium OCP and other hormones (eg danazol)
9)GYNAECOMASTIA-CAUSING DRUGS DISCOS:
Digoxin, Isoniazid Spironolactone, Cimetidine, Oestrogens, Stilboestrol
10)METHYLDOPA SIDE EFFECTS (METHYLDOPA):
Mental retardation, Electrolyte imbalance, Tolerance, Headache/ Hepatotoxicity, psYcological upset Lactation in female, Dry mouth, Oedema, Parkinsonism, Anaemia (haemolytic)
11)ANTIRHEUMATIC AGENTS (disease modifying): members 9CHAMP):
Cyclophosphamide, Hydroxycloroquine and choloroquinine, Auranofin and other gold compounds Methotrexate, Penicillamine,
12)ANTIARRHYTHMICS: class III members BIAS:
Bretylium ,Ibutilide, Amiodarone, Sotalol
13)PHENYTOIN: ADVERSE EFFECTS (PHENYTOIN):
 P-450 interactions, Hirsutism, Enlarged gums, Nystagmus, Yellow-browning of skin, Teratogenicity Osteomalacia ,Interference with B12 metabolism (hence anemia), Neuropathies: 9vertigo, ataxia,) and headache
14)SODIUM VALPROATE SIDE EFFCCTS;(VALPROATE)
Vomiting, Alopecia, Liver toxicity, Pancreatitis/ Pancytopenia ,Retention of fats (weight gain) Oedema (peripheral oedema) ,Appetite increase, Tremor ,Enzyme inducer (liver)
15)STEROIDS: SIDE EFFECTS    (BECLOMETHASONE):
Buffalo hump, Easy bruising, Cataracts, Larger appetite, Obesity, Moonface ,Euphoria, Thin arms & legs, Hypertension/ Hyperglycaemia, Avascular necrosis of femoral head, Skin thinning, Osteoporosis ,Negative nitrogen balance, Emotional liability
Vomiting: extra GI differential 9VOMITING):
Vestibular disturbance/ Vagal (reflex pain), Opiates, Migrane/ Metabolic (DKA, gastroparesis, hypercalcemia), Infections, Toxicity (cytotoxic, digitalis toxicity),  Increased ICP, Ingested alcohol Neurogenic, psychogenic, Gestation

16)HMG-COA: • SIDE EFFECTS: (HMGCoA)
Hepatotoxicity, Myositis [aka rhabdomyolysis],Contraindications, Girl during pregnancy/ Growing children • Interactions:, Coumarin/ Cyclosporine,
17)AMIODARONE: ACTION, SIDE EFFECTS (6 P'S):
Prolongs action, potential duration, Photosensitivity, Pigmentation of skin, Peripheral neuropathy Pulmonary alveolitis and fibrosis, Peripheral conversion of T4 to T3 is inhibited -> hypothyroidism    
18)MAOIS: INDICATIONS( MAOI'S):
Melancholic [classic name for atypical depression], Anxiety ,Obesity disorders [anorexia, bulemia] Imagined illnesses [hypochondria], Social phobias (_ Listed in decreasing order of importance. _ Note MAOI is inside MelAnchOlIc).
19)ANTIPARKINSON DRUGS( SALAD)
 Selegiline, Anticholinenergics (trihexyphenidyl, benzhexol, ophenadrine), L-Dopa + peripheral decarboxylase inhibitor (carbidopa, benserazide), Amantadine, Dopamine postsynaptic receptor agonists (bromocriptine, lisuride, pergolide)

20)METABOLISM ENZYME INDUCERS
Randy's Black Car Goes Putt Putt and Smokes":
Rifampin, Barbiturates, Carbamazepine, Grisoefulvin, Phenytoin, Phenobarbitone, Smoking cigarettes
21) ZERO ORDER KINETIC DRUGS   (PEAZ)
 Phenytoin, Ethanol, Aspirin, Zero order _ Someone that pees out
22)THERAPEUTIC INDEX FORMULA (TILE)      TI = LD / ED
23)PREANASTHETIC MEDICATION (HOSANA this is a christian word.)
H-H2blockers, O-opeoids ,S-sedatives,-antianxiety A-anticholenergic, N-neuroleptics, A-antiemetics 24)ANTI EPELEPTIC DRUGS (Dr.BHAISAB's New PC.)
D...deoxy barbiturates, B...barbiturates, H....hydantoin, A.. aliphatic carb acids, I....iminostilbenes S....succinimides, B....BZD's N.... newer drugs, P....Phenyltriazines, C... cyclic gaba analogues
25)ADVERSE EFFECTS OF TETRACYCLINS-(KAPIL DEV)
 K kidney toxicity, A antianabolic effect, P phototoxicity, I inc ICP, L liver toxicity, D diabetes insipidus, E enamel problems, V vestibular toxicity
26)ADRS OF CHLORAMPHENICOL (smart boys in girls hostel)
 S.....superinfections, B.... bone marrow depression ,I....irritative effects ,G.....Gray baby syndrome H...hypersensitivity
27)INHALATIONAL CORTICOSTEROIDS (Bed Bug Flew To Florida)
 B-BECLOMETHASONE DIPROPIONATE ,.B-BUDESONIDE,
 F-FLUTICASONE PROPIONATE ,   -TTRIAMCINALONE, F-FLUNISOLIDE

27)CAPTOPRIL SIDE EFFECTS ( CAPTOPRIL)
Cough, Angioedema/ Agranulocystosis, Proteinuria/ Potassium excess  ,Taste changes, Orthostatic hypotension, Pregnancy contraindication/ Pancreatitis/ Pressure drop (first dose hypertension), Renal failure (and renal artery stenosis contraindication)/ Rash, Indomethacin inhibition Leukopenia/ Liver toxicity
29)LITHIUM: SIDE EFFECTS (LITH):
Leukocytosis , Insipidus [diabetes insipidus, tied to polyuria], Tremor/ Teratogenesis Hypothyroidism .
30)CA++ CHENNEL BLOCKER USES
Cererbral vasospasm / CHF, Hypertension ,Angina, Suprventricular , tachyarrhythmia,  Migranes
31)MI: SIGNS AND SYMPTOMS (PULSE):
Persistent chest pains ,Upset stomach, Lightheadedness, Shortness of breath, Excessive sweating 32)MI: BASIC MANAGEMENT (BOOMAR):
Bed rest, Oxygen, Opiate, Monitor, Anticoagulate, Reduce clot size
33)LVF MANAGEMENT (FOAM)
 Frusemide 40mg iv, Oxygen,  Atrovent (& Ventolin) nebs, Morphine 2.5 - 5 mg ,Mitral Stenosis,
34)TREATMENT OF HEART FAILURE: (ABCDE)
 ACE inhibitors, Beta-blockers, Calcium channel blockers, Diuretics, Endothelin-converting enzyme inhibitors
35)LINES OF TREATMENT OF PULMONARY OEDEMA: (DOLMA)
 Digoxin, Oxygen, Lasix, Morfine, Aminophylline. (Dolma is a very famous food in the middle east


PHARMACOLOGY-GPAT/NIPER
1.Grey Baby Syndrome- Chloramphenicol
2.Pin Point Pupil-Morphine
3Reyes Syndrome- Asprin
4.Urine Coloration- Rifampcin
5.Frontal Headache- Indomethacin
6.Captopril-Persistant dry cough
7.Bleomycin-Pulmonary fibrosis
8.Vancomycin- Red man syndrome
 9.Nicotinic acid- Flush
10.Steven Johnsons syndrome- Allopurinol
sulphonamides-kernicterus
aminoglycosides-ototoxicity
discolouration of teeth-tetracyclines
doxorubucin & duanorubucin- cardiomyopathy.
chloroquine- cardiotixicity
doxycycline- esophageal ulceration
 vincristin & vinblastin- neuropathy
cyclophosphamide- alopecia
cimetidine & spironolactone- gynaecomastia
EFFECTS OF DRUGS DURING PREGNANCY ON FOETUS
antiepileptics-neuraltube defect
 warfarin-cleft palate
thalidomide-phocomalia
alcohol-cranial bone formation impairment

ANTIDOTES
benzodiazepine-flumazenil                                                                                                                   paracetamol-N-acetylcysteine                                                                                                                 Morphine-naloxone                                                                                                                                        nitrites-methylene blue                                                                                                                 organophosphurus compd.-DAM,PAM,Atropin                                                                                        Atropine-Physostigmine                                                                                                                                            lead-BAL                                                                                                                                                          cyanide-edetate+amyl nitrite
MOA of some common drugs
1.Nalidixic Acid-Prevent DNA sysnthesis                                                                                                 2.Dapsone-Folic acid sysntheses inhibitor                                                                                                   3.Vinca alkaloid-Mitotic Spindle formation prevention                                                                  4.anthracycline-Intercalation of DNA                                                                                          5.Methotraxate- Folic acid reductase inhibitor.                                                                                  6.Warfarin-Vit k antagonist                                                                                                                    7.Zidovudine- Inhibits the enzyme reverse tranascriptase ,preventing DNA replication 8.Metronidazole- disruption of helical structure of DNA                                                                9.Tetracycline- Inhibits Protein smyntheses by acting on 30 S unit of ribosome                    10.Erythromycin- Inhibits Protein smyntheses by acting on 50 S unit of ribosome              11.Chloroquine- Binds and alters properties of microbial and fungal DNA                                12.Diazepam- GABA facilitator                                                                                                   13.Acetazolamide- Carbonic anhydrase inhibitor                                                                              14.Allopurinol- Xanthine oxidase inhibitor,inhibitor of uric acid                                         15.Fluconalzole- P450 enzyme 14α-demethylase Inhibitor                                                  16.Salbutamol-Beta 2 receptor agonist                                                                                             17.Tolnaftate- Inhibit squalene epoxidase which is necessray for ergosteral syns of fungal cell wall 18.Griesofulvin-inhibits fungal cell wall activity                                                                      19.Chloramphenicol-Inhibition of Protein syntheses                                                                       20.Levodopa- Replenish Brain deleted dopamine

 PHARMACOGNOSY-GPAT
1.Baljet test- Cardiac glycosides                                                                                                                      2.Born Trager test- Anthraquinone glycosides                                                                                          3.Modified Born Trager test                                                                                                                             4.Borex test- Aloes                                                                                                                                   5.Boudouin's test- Seasame oil                                                                                                                6.Bardfoed's test- Carbohydrates                                                                                                                 7.Biuret test- Proteins                                                                                                                                8.Curaploin's test- Aloes                                                                                                                             9.Murexide test- Purines/xanthines                                                                                                                10.Carr price test- Vitamin A                                                                                                                      11.Fiehe's test- Artificial ibvert sugar as adultrant in honey                                                                    12.Foam test- Saponin                                                                                                                                 13.Grignard reaction- Cyanogenetic glycosides                                                                                              14.Gold beater skin test- Tannins                                                                                                                          15.Hal phen's test- Cotton seed oil as adultrant                                                                                     16.Haemolysis test- Saponins                                                                                                                         17.Klung's test- Aloes                                                                                                                                            18.Keller killianin test- Desocy sugar in digitalis                                                                                             19.Keris test- Rancidity of fats and oil                                                                                                            20.Legal test- Cardiac Glycosides                                                                                                          21.Lieberman burchard test- steroids                                                                                                      22.Ergotoxin Test- Ergot                                                                                                                                 23.Barford test- Carbohydrates                                                                                                                 24.Molisch Test- Carbohydrates                                                                                                                 25.Dragondroff's Test- Alkaloids                                                                                                                     26.Mayer Test- Alkaloids                                                                                                                            27.Wagner's Test- Alkaloids                                                                                                                                  28.Vitali Morin's Test- Alkaloids                                                                                                                                             29.Van Urk's Test- Ergot                                                                                                                                      30.Millon's Test- Protein

 1.Selivanoff's Test- Kenotic Carbohydrates                                                                                              2.Kedde's Test-Cardiac glycosides                                                                                                           3.Raymond Test-Cardiac glycosides                                                                                                                  4.Froth formation test- Saponin glycosides                                                                                                 5.Salkowski Test-Triterpenoids
DRUGS & SYNONYMS
1.Bavchi-Psoralea                                                                                                                                                  2.Indian Tobacco-Lobelia                                                                                                                              3.Kalmegh-Andrographis                                                                                                                                        4.Wild Saffron-colchicum                                                                                                                                5.Devil's Dung-Asafoetia                                                                                                                                   6.Calabar Bean-Physostigma                                                                                                                                7.Ma Huang- Ephedra                                                                                                                                      8.Rattle Snake root-Senega                                                                                                                             9Chinese Cassia- Cinnamon                                                                                                                           10.Panama Wood-Quillaria Bark                                                                                                               11.American wormseed-Chenopodium                                                                                                      12.Bishop's Flower-Visnaga                                                                                                                                       13.Fox Glove-Digitalis                                                                                                                                      14.Scammony Root-Ipomea                                                                                                                          15.Betel Nut-Areca Nut                                                                                                                                          16.Bitter Apple-Colocynth                                                                                                                              17.Vidang-Gurmar                                                                                                                                                     18.Our Lady's Thistle-Catharanthus                                                                                                            19.Flaxseed-Linseed                                                                                                                                        20.Hippo-Ipecac                                                                                                                                                 21.Indian Squill-Urgenia                                                                                                                     22.Chaulmooggra Oil-Hydnocarpus                                                                                                           23.American Podophyllum-May apple                                                                                                         24.Salad Oil-Olive Oil                                                                                                                                          25.Bitter Wood-Quassia                                                                                                                                               
The following are mucilagenous in nature..                                                                                                                 1)leaf epidermis of senna                                                                                                                                             2)seed epidermis of linseed                                                                                                                                        3)seed endodermis of fenugreek                                                                                                                               4)bark of cinnamon                                                                                                                                                   5)algae of agar                                                                                                                                                 6)mesophyll of squill

 PHARMACOGNOSY-GPAT
1-Liquorice- Ulignified Septate fibre
2-Solanacoeus Plants- Anisocytic stomata
3-Rhubarb- Star spots
4-Squill- Ca oxide raphides
5-Cardamom- Clothing of glandular trichome
6-Quillaria- Thin membrane arillus
7-Digitalis- Rhytidomes & Glandular Trichomes
8-Atropa Belladona- Anisocytic Stomata
9-Verbascus Thapsus- Clusters of Ca Oxalate
10-Artemisia- T-Shaped Trichomes
11-Stromanium- Phloem Fibres
12-Nuxvomica – Lignified trichomes
13-Fennel- Reticulate lignified trichomes
14-Coriander- Wavy sclerenchyma
15-Indian Dill- Lateral ridges with vascular bundle
16-Anise- Branched & unbranched vittae
17-Cinnamon- Absence of cork & cortex
18-Ginger- Non Lignified vessels & starch grains , Endodermis with no starch
19-Collapsed Endodermis
20-Caraway-Collapsed Parenchyma
21-Chenopodium-Epidermis with no trichomes
22-Chirata- Stomata on lower surface only with no trichomes
23-Cinchona - Large sclerenchymatous bast cells with Medullary ray.
24-Cinnamon- Parenchyma cells with starch.
25-Colchicum- Spiral Ducts, Parenchyma with starch
26- Coriander- Prismatic and aggregate crystals of calcium oxalate                                                                                       27-Saffron- Trichome of stigma                                                                                                                                              28-Turmeric- Parenchyma with pasty starch                                                                                                                            29-Digitalis- Glandular trichomes                                                                                                                                           30-Euclyptus- Crystal bearing fiber                                                                                                                                      31-Gentian- Large reticulate ducts                                                                                                                                        32-Liquorice- Parenchyma with crystals and starch                                                                                                                    33-Hycyamus- Endosperm tissue with proteid granules and oil.                                                                                                                           34-Ipecac- Parenchyma with raphides                                                                                                                                      35-Mentha- Trichomes, simple, showing cuticular markings (a medium    sized trichome).                                                                                                                        36-Pilocarpus- Aggregate crystals of calcium oxalate.                                                                                                         37-Podophyllum- Reticulate ducts and tracheids, Spiral duct, Aggregate crystals of calcium oxalate, Cork                                                                          38-Quassia- Medullary ray with starch, Large porous duct                                                                                                      39-Rheum- Parenchyma with starch, resin and crystals, Reticulate ducts.                                                                           40-Senega- Parenchyma with fat, Cork & Porous duct                                                                                                       41-Senna- Bast of vascular bundles, Crystal bearing fibers from vascular tissue                                                                                                                                  42-Stromanium- Parenchyma cells of petiole                                                                                                                     43-Strophanthus- Endosperm tissue, showing oil and crystals, Outer tissue with granular proteid matter and starch 44-Tobbaco- Parenchyma (collenchymatous) from midrib,Leaf parenchyma with chlorophyll.                                                45-Ginger- Parenchyma with starch and one cell with resin                                                                                               46-Belladona- Tracheids and spiral duct, Leaf parenchyma cells with crystals,Bast Cells, Porous ducts &Crystal Sand                                                                                                                                                                             Stomatal Index- Leafy drugs
1.Type of Stomata                                                                                                                                                      Anomocytic- Ranunculaceae                                                                                                                                               Paracytic- Rubiaceae                                                                                                                                                      Anisocyclic- Cruciferae                                                                                                                                                   Diacyclic-Caryophyllaceae                                                                                                                                              2.Total Ash Value- Eucalyptus Oil                                                                                                                                 3.Iodine Value- F.O. having more unstaturated fatty acid                                                                                       4.FibreLength- Bark                                                                                                                                                   5.Cineole Factor- Eucalyptus                                                                                                                                           6.Swelling Index- Isphagula
MULTICELLULAR  MEDULLARY RAYS ARE SEEN IN??                                                                                                                          2  .candelebra trichomes are found in??                                                                                                                   3.pungency of ginger,pepper,capsicum are due to presence of?                                                                                   4.name one bicyclic monoterpene?                                                                                                                                    5.use of dioscorea??

1-Dictoxylon
2-Verbascum
3-Ginger-Phenolic ketone of oleoresin
4-Camphene
5-precursor for synthesis of steroids,orla contraceptives & treatment of rheumatoid arthritis

emetin+opium=dovers powder

 ADVERSE DRUG REACTIONS-GPAT
 Abortion, miscarriage or uterine hemorrhage associated with Misoprostal (Cytotec), a labor-inducing drug (this is a case where the adverse effect has been used legally and illegally for performing abortions)
 Addiction to many sedatives and analgesics such as diazepam, morphine, etc.
 Birth defects associated with Thalidomide and Accutane.
 Bleeding of the intestine associated with aspirin therapy
 Cardiovascular disease associated with COX-2 inhibitors (i.e. Vioxx)
 Deafness and kidney failure associated with gentamicin (an antibiotic)
 Death, following sedation in children using propofol (Diprivan)
 Dementia associated with heart bypass surgery
 Depression or hepatic injury caused by interferon
 Diabetes caused by atypical antipsychotic medications (neuroleptic psychiatric drugs)
 Diarrhea caused by the use of orlistat (Xenical)
 Erectile dysfunction associated with many drugs, such as antidepressants
 Fever associated with vaccination (in the past, imperfectly manufactured vaccines, such as BCG and poliomyelitis, have caused the very disease they intended to fight).
 Glaucoma associated with corticosteroid-based eye drops
 Hair loss and anemia may be caused by chemotherapy against cancer, leukemia, etc.
 Headache following spinal anesthesia
 Hypertension in ephedrine users, which prompted FDA to remove the status of dietary         supplement of ephedra extracts


 Insomnia caused by stimulants, Ritalin, Adderall, etc.
 Lactic acidosis associated with the use of stavudine (Zerit, for anti-HIV therapy) or metformin (for diabetes)
 Liver damage from paracetamol
 Melasma and thrombosis associated with use of estrogen-containing hormonal contraception such as the combined oral contraceptive pill
 Irreversible Peripheral neuropathy associated with the use of fluoroquinolone medications
 Rhabdomyolysis associated with statins (anti-cholesterol drugs)
 Seizures caused by withdrawal from benzodiazepine

 Drowsiness or increase in appetite due to antihistamine use. Some antihistamines are used in sleep aids explicitly because they cause drowsiness.
 Stroke or heart attack associated with sildenafil (Viagra) when used with nitroglycerine
 Suicide, increased tendency associated to the use of fluoxetine and other SSRI antidepressants
 Tardive dyskinesia associated with long-term use of metoclopramide and many antipsychotic medications
 Spontaneous Tendon rupture associated with fluoroquinolone drugs [20] even occurring as late as 6 months after treatment had been terminated


 FEW IMPORTANT PHYTOCHEMICAL TESTS

Alkaloids                  (  Dr. Praveeen Amrin  HMT Watch )
Dragondroff test
Procalonic acid test
Ammonia Rinker Test
Hager’s test
Mayor’s Test
Tannic acid test
Wagner’s test
Carbohydrates           (BOMBS)
Barfoed’s Test
Osazone Formation test
Molisch Test
Benedict Test
Salvinoff Test

Proteins                  (HHH) (a wrestler) MCBX (type of magnet)
Heat test
Hydrolysis test
Hopkins-Cole
Millon’s Test
Cystine Test
 Biuret test                                                                                                                                                     Xanthoproteic test
Cardiac Glycosides       (Bengal like kolkatta knight riders )                                                                   Baljet test                                                                                                                                                                Legal test                                                                                                                                                                    Killer killani test                                                                                                                                                   Kedde’s test                                                                                                                                                     Raymond’s test
Tannins               (Very Good Female PG College Classes)                                                                          Vanillin HCL Test                                                                                                                                                          Gelatin test                                                                                                                                                         Ferric chloride test                                                                                                                                          Phenazone test                                                                                                                                                             Gold-beaters test                                                                                                                                                   Catechin test                                                                                                                                                  Chloroacetic acid test
Anthraquinone Glycosides          (BUMP)                                                                                     Borntrager’s tests                                                                                                                                                      UV Test                                                                                                                                                               Modified Borntrager’s Test                                                                                                                                Potassium hydroxide test
Amino acids   (EVM has new polling strategies, still few says X- manual Voting was Correct) Ehrlich reaction                                                                                                                                                         Van Slyke                                                                                                                                                                    Millon reaction                                                                                                                                                              Hopkins-Cole reaction                                                                                                                                                                                         Ninhydrin Test                                                                                                                                                                Pauly’s Test                                                                                                                                                                      Sagakuchi Test                                                                                                                                                                  Sulfur Test                                                                                                                                                                            Folin Coicalteau’s Test                                                                                                                                                          Sullivan reaction                                                                                                                                          Xanthoproteic reaction                                                                                                                                        Cystine Test
ANTI DOTES
benzodiazepine-flumazenil                                                                                                                           paracetamol-N-acetylcysteine                                                                                                               Morphine-naloxone                                                                                                                                  nitrites-methylene blue                                                                                                             organophosphurus compd.-DAM,PAM,Atropine                                                                                                         Atropine-Physostigmine                                                                                                                                  lead-BAL                                                                                                                                                                          cyanide-edetate+amyl nitrite                                                                                                                               (DAM- diacyl monooxime PAM-pyridine-2-aloxime BAL-british anti lewisite )
Antibiotics containing
1 aminoacid-cycloserine,chloramphenicol
2 aminoacids-cephalosporins,penicillins
sugar-erythromycin
polycyclic units-neomycin
pentylene tetrazole-brainstem stimulant
nikethamid-respiratory stimulant
strychnine-spinal stimulant
Urine Color Changes
Orange- Rifampcin,Phenozopyridine,Doxorubicin,Warfarin
Blue-Amitryptalline,Indomethacin
Red/Brown-Food Dyes...
Pink-Beet Root
Golden Yellow-Excess of laxatives
Neon Yellow- Excess of vitamin supplements
some of ADR'S
sulphonamides-kernicterus
aminoglycosides-ototoxicity
discolouration of teeth-tetracyclines

transplants that DO NOT require immunosuppression-
Cornea C
Uterus U
Testis T
Brain Beclamethasone
Thymus Treatment
these organs lack lymphatic channels.... hence no chance of antigens reaching sec. lymphoid organs for rejection.

Wiskott- Aldrich Syndrome (WAS) - triad-
W-Weeping skin lesions- eczema
A- Absent platelets- thrombocytopenia
S- Severe immunodef. of B and T cells

Endotoxin features →(ENDOTOXIN:)
Endothelial cells/ Edema
Negative (gram- bacteria)
DIC/ Death
Outer membrane
TNF
O-antigen
X-tremely heat stable
IL-1
Nitric oxide/ Neutrophil chemotaxis

Teratogens: placenta-crossing organisms        (ToRCHeS):
Toxoplasma
Rubella
CMV
Herpes simplex, Herpes zoster (varicella), Hepatitis B,C,E
Syphilis
· Alternatively: TORCHES: with Others (parvo, listeria), add HIV to H's, Enteroviruses.
Gram+: bacterial cell wall
· Gram+ has:
+hick pepidoglycan layer.
+eichoic acid in wall.
Gram Positives Stain Purple (violet-blue)
because of their thick Peptidoglycan layer

Mycobacterium tuberculosis: culture identification      →("Rough, Tough, Buff"):
Rough: colony isn't smooth but rough like breadcrumbs.
Tough: colony stuck to plate well, and tough to remove.
Buff: buff is a color, a cream/coffee shade

Vaccines: types      (STARK):
Subunit
Toxoid
Attenuated [live]       
Recombinant ,   &  Killed [inactivated]
All type II reactions are related with organ specific autoimmune diseases like..
Multiple Sclerosis
Myesthenia Gravis
Chronic Thyroiditis
Graves disease
Type 1 Diabetes
Pernicious Anemia
ITP
Guillian Barre Syndrome

and all type III reactions are related to systemic autoimmune diseases like
RA
SLE
Good pastures syndrome

the concept used in Indirect flurescent Antibody (IFA)test, ELISA and Western blot...... are all the same...
that they all need a known Ag + pts serum with AB against the Ag + Antihuman gama

Globulin.....with specific labels

IFA= Test ag+ pts serum+ anti- human gama globulin labeled with fluoresent dye

ELISA= test ag( P24 ag) + pts serum+ anti-Human gama globulin labeled with an enzyme

western Blot= test ag ( GP120, GP 41, P24) + Pts serum+ anti-human gama globulin labeled with an enzyme
Antipseudomonal antibiotics

how to kill pseudomonas
1-tie it up (ticacillin)
2-hit it with a pipe (pipercillin)
3-(i think this one is right) run over it with a car carbenicillin.
We made up a lot of these for micro and pharm

"Common cold (acute infectious rhinitis, coryza) is PRIMArily caused by":
Paramyxoviruses
Rhinoviruses
Influenza viruses
Myxoviruses
Adenoviruses


1 x 8 and 2 x 4
MHC classI is associated with CD8 T cell
MHC classII is associated with CD4 T cell

1 x 4 and 2 x 2
Type1 IDDM is hypersensitivity type4
Type2 NIDDM is hypersensity type2 (noncytotoxic)
Toxins that increase ‘cAMP:’
CHOLERA
ANTHRAX
M=E.coli labile toxin
PERTUSSIS

antibiotics c/I in pregnancy   →(SAFETY )
S - SULPHONAMIDES
A – AMINOGLYCOSIDES
F - FQs
E - ERYTHROMYCIN ESTOLATE
T - TETRACYCLIN
Y - clindamYcin


antihelmenthic ;

DIFFICULT - DISCHLORPHEN
QUESTION - QUINACRINE
NOT - NICLOSAMIDE
ANSWERED - ASPIDIUM

drugs causing pul fibrosis
                          →(BBC MAN):
B-BLEOMYCIN, B-BUSULPHAN, C-CYCLOPHOSPHOMIDE, M-METHOTREXATE,                    A-AMIODARONE, N-NITROFURANTOIN

drug causing erectile dysfunction
.
                                  →(STOP erection)
S-SSRI (FLUOXETINE)
T-THIORIDAZONE
O-methldOpa
P-PROPRANALOL

HYPERTHYROIDISM
. signs and symptoms of hyper ‘THYROIDISM ‘
Tremor
Heart rate up
yawning(fatigued)
Restlessness
oligomenorrhea/amenorrhea
Intolerance to heat
Diarrhea
Irritability
Sweating
Muscle wasting/weight loss

NNRTI (non nucleotide revers transcriptase inhibitors)
.
                                 →(END)
E- efavirenz
N- nevirapine
D- delavirdine

NSAID classification
nonselective COX inhibitors       →(OF(H)SP(PP)In (cricket))
O-Oxicam
F-fenamates
H-heterocyclic ary acet acid
S-salicylate
P-propionic acid der
P-para amino phenol
P-pyrazolone
In-indole

VIRAL LIVE VACCINES     →(MY MR VIP)
M-Mumps
Y-YellowFever
M-Measles
R-Rubella
V-V aricella
I-Influenza, &  P-Pox

Wolf Parkinson''s White Syndrome
Type A = QRS Above Baseline
Type B = QRS Below Baseline

TOXINS ACTING BY INHIBITING PROTEIN SYNTHESIS
→("Dont text Synthesisetext Proteins" )

D(ont)- DIPTHERIA TOXIN
S(ynthesise)-SHIGA TOXIN
P(roteins)-PSEUDOMONAS TOXIN

ORGANOPHOSPHATE POISONING
                                  →(DUMBLES)
D=diaphoresis
U=urination
M=meiosis
B=bowl motility(incresed)
L=Lacrimation
E=emesis
S=salivation

non polar amino acids
.
                               →(PROf.V M PATIL) for
proline, Valine,  Methionine, Phenylalanine, Alanine, Tryptophan,Isoleucin,  Leucin

 Notes for GPAT entrance exam:
. Aliskiren is a renin inhibitor
. Penicillin amidase engyme convert penicillin into 6-APA in alkaline conditions but in acidic condition it is used to sythesise penicillin from 6-APA.
. read chapter Bioinformatics and computational biology in HARPER mainly about BLAST.
.Preclinical testing- animal testing is done during preclinical testing.
. Clinical trials- done after preclinical testingdone after pical testing
Phase 0: microdosing is directly given to patient without any preclinical testing.
Phase 1: done on 20-50 healthy volunteers for estimation of safety and tolerability of drug.
Phase 2: also called controlled clinical trials. Done on upto 1000 population of patients for estimation of effectiveness (efficacy) of drug.

 Phase 3: also called expanded controlled or uncontrolled clinical trials. Done on upto 3000 to 10000 popullation of patients. They bring about additional information about effectiveness and safety.
Phase 4: evaluate the post marketing survivelence of drug

 Drug development process steps-
-Target identification and characterization ( target means any enzyme,protein or receptor)
- Synthesis of lead molecules
- screening of lead molecules
-Preclinical tesing
-Clinical trials
.on an average any new drug molecule take about 12 to 15 years to reach the patients and the cost of us$ 400 to 650 million.
-Read birch reduction reaction
Animal models:
.Rotarod apparatus: used to determine muscle relaxant property of any drug in mice(eg Diazepam)
.catalepsy: it is a condition cherecterised by loss of consciousness with rigidity of muscles that keep limbs in fixed condition( haloperidol is used to induce catalepsy during animal experimentations)

.PA2 value: defined as negative logarithm of molar concentration of antagonist which will reduce effect of agonist to 50% of its maximm value.
SDS-PAGE( Sodium dodecyl sulphate-poly acryl amide gel electrophoresis): this technique is widely used to separate proteins according to their size or electrophoretic mobility . samples having identical charge/mass ratio.
GHOST peak in chromatography: peak arises due to impurities. . read polymerase chain reaction
. Alziemer disease: B amyloid and tou protein level increased in brain
. Pakisonism: sinuclein and perkin protrin level increased in brain
RT-PCR: laboratory technique for amplifying a defined piece of a ribonucleic acid(RNA) molecule. The RNA strand is first reverse transcripted in its complimentary DNA, followed by amplification of the resulting DNA using PCR.
. Read hybridoma technology
Biostatistics:
. Correlation: it determines the association between two or more variables and concerned with measuring the strength of relationship between variables
. Regression : it is helpful in assernating the probable form of the relationship between variables. It describe the dependence of a variable on an independent variable
. ANOVA: it is most powerful statistical tool. It is general method of analyzing data from desined experiments whose objective is to compare two or more group means
. t-test: it is a special case of anova in which only two means are compared. For applying t- test population varience must be unknown and sample size should be small(less than 30)
. level of significance(alpha): it is the probability of rejecting true null hypothesis
. z-test: applied when population varience is known and sample size is large
. Type first error: commited when a true null hypothesis is rejected
. Type second error: commited when a false null hypoyhesis is not rejected
. mean: we already know
. mode: the mode is a set of values is that value which occurs most frequently
.median: it devides the set into two equal parts(middle value) when all values have been arranged in order of magnitude
. standard variation: it is a measure of dispersion. When it increases variability increases
. in case of normal distribution mean mode median are all equal
. standard error of mean: it measures the precision of the mean. Smaller the SEM, the more precise is mean
. read about proteomics and genomics


ANALGESICS
Opioid receptors are a group of G protein-coupled receptors with opioids as ligands.[1][2][3] The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. The opioid receptors are ~40% identical to somatostatin receptors (SSTRs). Opiate receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract.
There are four major subtypes of opioid receptors:[12]
Receptor
Subtypes
Location [13][14]
Function [13][14]
delta (δ)
DOP
OP1 (I)
δ1, δ2
kappa (κ)
KOP
OP2 (I)
κ1, κ2, κ3
mu (μ)
MOP
OP3 (I)
μ1, μ2, μ3
μ1:
μ2:
μ3:
  • possible vasodilation
ORL1
  • anxiety
  • depression
  • appetite
  • development of tolerance to μ agonists
Opium alkaloids
Phenanthrenes naturally occurring in (opium):
Preparations of mixed opium alkaloids, including papaveretum, are still occasionally used.

Esters of morphine
Ethers of morphine
Semi-synthetic alkaloid derivatives
Synthetic opioids                                 
Anilidopiperidines


Diphenylpropylamine derivatives
Benzomorphan derivatives
Oripavine derivatives
Morphinan derivatives
Others

ANS RECEPTORS
Target
β1, (β2): increases
M2: decreases
SA node: heart rate (chronotropic)
β1, (β2):[5] increases
M2: decreases
Atrial cardiac muscle: contractility (inotropic)
β1, (β2):[5] increases
M2: decreases
β1:
increases
conduction
increases
cardiac muscle automaticity[5]
M2:
decreases conduction
Atrioventricular block[5]
β1, (β2):
increases contractility (
inotropic)
increases
cardiac muscle automaticity[5]
---
Target
α1:[6] contracts; β2:[6] relaxes
M3: relaxes[5]
α1:[7] constricts
---
α1 and α2:[8] constricts[5]
---
β2:dilates[9]
---
α: constricts
---
α: constricts
---
α1:[10] constricts[5]
---
α1:[11] constricts
M3: dilates
α: constricts
M3: dilates
β2: dilates
---
β2: dilates
---
α1 and α2:[12] constricts
β2: dilates
---

Other
Target
α2: aggregates
---
β2: inhibits
---
Target
β2:[6] relaxes (major contribution)
α1: contracts (minor contribution)
M3:[6] contracts
The bronchioles have no sympathetic innervation, but are instead affected by circulating adrenaline[5]
Target
α1: Dilates
(causes
mydriasis)

-
M3: contracts
(causes
miosis)
β2: relaxes
(causes long-range focus)
M3: contracts
(causes short-range focus)
Target
salivary glands: secretions
β: stimulates viscous, amylase secretions
α1: stimulates
potassium secretions
M3: stimulates watery secretions
β: stimulates protein secretion[13]
---
β1:[6] renin secretion
---
---
M1: Gastric acid secretion
---
adipose cells
β1,[6] β3: stimulates lipolysis
---
α1, α2,[14] β2: decreases
M3, (M1):[5] increases
α1,[6] α2,[5] β2: contracts
M3:[6] relaxes
no effect[5]
M3: secretes
Target
α2: decreases insulin secretion from beta cells, increases glucagon secretion from alpha cells
M3:[15][16] increases secretion of both insulin and glucagon.[15][16]
N (nicotinic ACh receptor): secretes epinephrine and norepinephrine
---
Target
β2,[6] β3:[17] relaxes
M3:[6] contracts
α1:[6] contracts
M3:[6] relaxes
Target
α1: contracts (pregnant[5])
β2: relaxes (non-pregnant
[5])
---
α1: contracts (ejaculation)
M3: erection
Target
sweat gland secretions
M:[6] stimulates (major contribution); α1: stimulates (minor contribution)
---
α1: stimulates
---
ADRENERGIC DRUGS 
1)Based on receptors
Class of receptor
Agonist
Antagonist
NON SELECTIVE


indirecting acting
 Einpephrin,,Amphetamine
Tyramine ,Cocain

Direct acting
Nor ephinephrine
Isophrenaline
Dopamine
Epphrhineine
Bucindolol
Corvedilol
Medroxylol
Labetelol

Class of receptor
Agonist
Antagonist
α-RECEPTOR


Non selective-α
Tetrahydrazoline
Oxymetazoline
xylometazoline
Phenoxybenzamine
Phentolamine
Tolazoline

selective-α1

Phenylephrine
mephenteramine Methoxamine
Metaraminol


Prazosine
Rauwolscisine
Indoramine
Doxazocine
Alfuzocine
Terazocine,
tampuzocin
selective-α2
Clonidine
Moxonidine
Guanabenze
Guanafacine
α-Methyldopa
Yohimbine
Tolazoline,idazoxan,efaraxan

Class of receptor
Agonist
Antagonist
β-RECEPTOR


Non-selective
Isoproterinol
,Oxprenolol Propranolol
Nadolol,pindolol,Timolol
sotalolPentobutalol,
Cartelol
Selective- β1
Xanoterol,
dobutamine,
isoprenaline,
Prenolteral.
Atenolol,metaprolol
Acebutalol,practolol
Betaxolol,Esmolol,Celiprolol,
Nebivolol,Bisoprolol
Selective- β2




ritodrine Metaproterinol
Fenoterol,bitolterol
Formterol,pirbuterol
Salmeterol,salbutamol
Butoxalol
Selective- β3
BRL37344




2)Based on  MOA
i)Directly acting;
   ex;Dopamine, Nor-adrenaline, Adrenaline→endogenous catacol amins
    Isoprenaline, Dobutamine,Dopaxamine, Fenaldopam→exogenous catacol amins
 ii) In directly acting   (uptake-I blockers)
   ez; Cocain, Tricyclic antidipressants, Amphetamine, Methylphenidate, Modafinil
iii)mixed acting;
   ex; Ephedrine, Pseudo ephedrine.
3)Based on use
i)Agents to rise B.P in shok;
   Ex; Dopamine, Nor-adrenaline , Ephedrine , Phenylephrine
,      mephenteramine,  Methoxamine , Metaraminol
ii) Branchodilators
   Ex; Salmeterol,Formterol,→long acting
salbutamol, terbutaline→short acting
iii)Cardiac stimulants  →(DADI)
     ex; Dopamine, Adrenaline, Dobutamine,Isoprenaline, 
iv) CNS stimulants
    ex; , Modafinil, Amphetamine,Dextro amphetamine,
v) Local vaso constrictors
     ex; adrenaline
vi)Nasal decongest
   ex; Oxymetazoline , Xylometazoline, Naphazoline,Phynylephrine, Phenyl propanolamine.
vii) For allergic Rxn.  (anaphylactic shok)
         ex;ephineprin
viii) anorectics
     ex; Dextro amphetamine, seibutramine, phenteramine
ix)Uterine relaxants
     ex; Salmeterol, Terbutaline, Isoxasprin, Retordine
4) Based on pharmacological difference
i) Agents with intrinsic sympathomimetic activity    → (cAMP)
  ex;  Celiprolol, Acebutalol, Mepindolol, Pindolol 
ii) Agents with  membrane stabiliging activity
     ex; Acebutalol, Butaxalol, propranalol,pindolol 
iii)  β-blockers  with anti oxidant activity
    ex; Carvedilol, Nebivolol

5) Based on therapeutic use
   i) Agents  for  cardiac arrhythmiasis 
       ex;  Sotalol,  Esmolol
ii) agents  with CHF
  ex;  Bisoprolol, carvedilol, 
     metaprolol, nebivolol →sustained released drugs.
iii) Agents for glaucoma
ex; timolol, pindolol, bufaxalol.
iv) migrant prophylaxis
ex: Propranalol, Timolol,
6)Based on genaration
i)  1st genaration
     ex;  Propranolol, Pindolol , Sotalol,  Timolol, Nadalol, pentobutalol
ii) 2nd generation  ( β2 selective)
     ex: Atenalol, Acebutalol, Bisoprolol, Esmolol, Metaprolol
iii) 3rd genarayion( with addition of α-blocking  & vasodulatory property)
     ex: Nebivolol, Carvedilol, Celiprolol, Labetilol

PARASYMPATHOMIMETICS
1)Directli acting agents
i) alkaloids;
ex: Muscarin, Aracholine, Pylocarpine
ii)Ach.esters;
ex: methocholine, Ach, carbacol.
2) revesible acting agents
Ex: Physostigmine, Neostigmine, Pyridostigmine, Endrostigmine,
(Rivastigmine, Donepezil →alzeimars drugs)
3) Irreversible acting agents
Ex: Carbaryl, Probaryl, Parathion, Malathion,  Ecothiopate  &
Nerve gases →soman, sarin, tabun




Choline esters    Susceptibility to     Muscarnine action     Nicotinic action
                            Choline esters   
Ach.chloride            ++++                          +++                              +++
Metha choline              +                             +++                             none
  Chloride
Bethanacol                 neglible                      ++                               none
   Chloride
Carbacol                     neglible                      ++                              +++
   chloride

ANTI CHOLINE ESTERASE  BASED ON CHEMICALS

Drugs                               Uses                                 apropriate D.O.A
1)Alcohals :                                           
 Edrophonium     --  myastheniagravis, ileus      -----------5-15 minutes
                                    Arrhythmia
2)Carbamates & related agents:
   Neostigmine      --        myastheniagravis, ileus    --------0.5-2hr
   Pyridostigmine    --     myastheniagravis        -------------3-6hr
   Ambeninium      --       myastheniagravis     ---------------4-8hr
    Physostigmine,   --     Gluacoma           --------------------0.5-2hr
   Demecarium       ---     Gluacoma               -----------------4-6hr
  3) Oragano phaspates:                        
      Ecothiopate       ---    Gluacoma         ---------------------100hr

PARASYMPATHOLYTICS
1)Natural alkaloids:
  Ex  aspirine , Hyocin  (scopalamine→ used in motion sickness & available in               trans dermal patches )
2) Semi synthetic derivatives:
Ex  Homatropine , Ipratropium bromide, Oxybutynin, Cyclopentolate,     Tropicamide, Dicyclomine, Pirenzepine, Glycopyrrolate

3)Sythetic derivatives:
i) Mydriatics:
ex  Tropicamide, Cyclopentanoline



ii) Anti secratory anti spasmodic;
 a)30  amines; Pirenzepine, Dicyclomine
b) Quarenary compounds: propantheline, Oxyphenonium, Isopropamide, Glycopyrolate,
3) vasoselective parasympathomimetic
  EX:Oxybutynin, Tolterodine,Flavoxate.
4) Antiparkinson drugs;
  Ex: Trihexyphenytyl(Benhexol),Procyclidine, Biperidine.

              
 NMJ .BLOCKERS

1)Centrally acting agents
Ex:  Diazepam, Methocarbamol, Chlorzoxazone, Baclofen, Gabapentine.
2) Periperally acting agents
i)drugs acting on NMJ:
   a)Depolarising
ex: Decomethonium, succinyl choline.
b) Non-depolarising blockers  (competitive blockers):
·        Short acting:
Ex: Mevacurium
·        Long acting:
Ex:  d-Tubocurarine, Pancuronium, Doxorubicine
·        Intermediate acting;
Ex; Vecurarium, Atracurium, Rocuronium

Others
Ex;  Botulinum




Dandroline: Directly acting  smooth muscle relaxant
d-Tubocurarine: 1st discovered drug in pharmacology
Pancuronium: synthetic agent which does not release histamine  & posses vagolytic action  so  cause tachycardia.
Atracurium: Undergoes  spantaneus degradation in plasma. ( half man elimination ---No-metabolism)
Mivacurium: Rapidly inactivated by plasma choline esterase  which cause histamine release.



Best of luck to All My friends…………….

“A doctor can give life to patients with medicine...
                           ‘‘But’’
A life to the medicine is given by pharmacist……’’


If there are  any mistakes..please forgive…….Me
                    &    correct  It……